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Discovery by University of Reading scientists paves way for development of better medical implants – University of Reading

Scientists from the University of Reading have discovered that proteins stick, slide and cluster on solid surfaces. The way in which proteins cluster on a surface affects their activity and the findings from this research will help to develop new materials for use in medical and dental implants.

Proteins are molecules which play a central role in biological processes, and form the basis of all living tissues. When a foreign material, such as a medical implant, is put into a living organism, then a layer of protein molecules will start to attach and grow on it. By using experiments and theories which have been developed to understand this growth, the researchers have identified the key steps which are important for proteins to form this layer.

The research shows that proteins first stick to a surface then they slide around until they meet each other and join together to form clusters. These clusters are also able to slide around, although not as quickly, and can then stick together to create even bigger clusters. This movement results in a surface which is covered in isolated islands of protein molecules separated by large areas of bare surface.

For medical and dental implants, knowledge about the arrangement of protein molecules on a surface is important, because it is these molecules which interact directly with the surrounding tissue. The way in which proteins initially attach to a surface influences how cells then grow and this has implications for the integration or rejection of any implanted material. If proteins were fixed at the first point of attachment, then this would create a very different surface distribution with different properties.

Dr Roger Bennett, from the Departments of Chemistry and Physics, said "Our work into the ways in which proteins attach and cluster on solid surfaces will help to develop better biocompatible materials for use in implants. In contrast to previous ideas, which were based on simple models, our experiments and modelling show the actual behaviour of proteins. Our research has investigated how proteins attach to surfaces by mimicking the immersion of artificial materials, such as medical and dental implants, in biological solutions, for example blood or saliva, then visualising the results by using a technique known as Atomic Force Microscopy."

ENDS

Notes for Editors

1) For all media enquiries, please contact Dr Lucy Chappell on 0118 378 7391, or email l.chappell@reading.ac.uk

2) The research will be published in Physical Review Letters on the 15th February 2008.

3) The work was funded by the MRC and was carried out at the University of Reading, using facilities located within the Centre for Advanced Microscopy (CfAM).

4) For more information about CfAM please see www.reading.ac.uk/cfam/

5) For more information about Nanoscience at Reading please see www.nano.reading.ac.uk/

6) All of the research for this project was carried out at the University of Reading. One of the authors, Paul Mulheran, now works at the University of Strathclyde.